NOBIVAC LYME

Dogs

Therapeutic Class

Diseases

Available Media

How ticks transmit disease to dogs…

How do you know if a vaccine is protecting your patients from Lyme disease?

Efficacy

Nobivac™ Lyme has been shown to produce borreliacidal antibodies that are highly effective in eliminating Borrelia burgdorferi from ticks and preventing infection in dogs1.

In a tick challenge study:

  • 30 8-week old puppies were randomly assigned to two groups
  • 15 vaccinates and 15 controls received either Nobivac™ Lyme or a placebo injection administered subcutaneously on Days 0 and 21
  • All dogs were challenged with live B. burgdorferi-infected ticks 3 weeks after the second dose
  • Ticks fed for 7 days, then were examined for B. burgdorferi 
  • Evaluations in dogs included skin biopsies, joint tissue analyses, and assessment for clinical signs of disease

 

Nobivac™ Lyme has also been shown to protect against Lyme disease-associated joint abnormalities.1


Nobivac™ Lyme provides a broad level of protection against subclinical and clinical signs of illness due to Lyme disease.1

In dogs vaccinated with Nobivac™ Lyme…

  • No B. burgdorferi were recovered from joint tissues
  • No inflammatory changes were seen in joint capsules 
  • No limb or joint disorders attributable to B. burgdorferi occurred 

  • No serologic evidence of exposure to B. burgdorferi was present

In control dogs…

  • 14 out of 15 had antibodies specific for B. burgdorferi
  • 10 out of 15 developed joint stiffness or lameness, or chronic joint inflammation (synovitis) 
  • 8 out of 15 had isolation of B. burgdorferi from the joint

Reference:
1. LaFleur RL, Dant JC, Wasmoen TL, et al. Bacterin that induces anti-OspA and anti-OspC borreliacidal antibodies provides a high level of protection against canine Lyme disease. Clin Vaccine Immunol. 2009;16:253–259.