CHORULON®

Chorulon is a sterile and effective preparation of chorionic gonadotropin.

Overview

Chorulon (chorionic gonadotropin) is a sterile and effective preparation of chorionic gonadotropin, which has been routinely used for nearly two decades to induce and synchronize the ovulation and spawning of various cultured fish species.

Chorulon provides the fish farmer with a tool to eliminate losses due to partial ovulation and spawning, as well as enhance egg quality, milt production, sperm volume and motility, and resulting fertilization rates. In comparison with the traditionally used crude fish pituitaries, Chorulon has several further significant advantages which have become increasingly important in today’s modern and intensive fish farming industry:

Chorulon is a hormonal spawning aid approved by the FDA in the USA for use in finfish (NADA 140-927). It is a freeze-dried preparation of human chorionic gonadotropin (hCG) for administration after reconstitution in the accompanying sterile diluent. It has luteinizing hormone (GtH-II)-like activity with little or no follicle stimulating hormone (GtH-I) or oestrogenic activity.

After reconstitution, Chorulon is administered via intramuscular injection just ventral to the dorsal fin for one to three injections. Any single injection should be administered, depending on the fish species, at a dose of 50 to 510 I.U./lb body weight (bw) for males and 67 to 1816 I.U./lb bw for females.

No withdrawal period is required for cows or brood finfish treated according to label directions. The total dose administered (all injections combined) should not exceed 25,000 I.U. (25 mL) per fish in fish intended for human consumption. Chorionic is a protein. In the unlikely event of an anaphylactic reaction, epinephrine should be administered. The administration of an antihistamine may also be indicated.

Fair Balance

Chorionic gonadotropin is a protein. In the unlikely event of an anaphylactic reaction, epinephrine should be administered. The administration of an antihistamine may also be indicated. No withdrawal period is required for cows or brood finfish treated according to label directions. The total dose administered (all injections combined) should not exceed 25,000 I.U. (25 mL) per fish in fish intended for human consumption.

For additional information, please see the product label.

Product Information

Description

Chorulon is a freeze-dried preparation of chorionic gonadotropin (human Chorionic Gonadotropin or hCG) for intramuscular administration after reconstitution. When reconstituted with the accompanying sterile diluent, each 10 mL vial contains 10,000 I.U. chorionic gonadotropin (equivalent to 10,000 USP Units chorionic gonadotropin) and 10 mg mannitol, with mono- and disodium phosphate to adjust the pH of the solution.

Indications

Finfish: Chorulon is indicated for use as an aid in improving spawning function in male and female brood finfish.

Dosage

Chorulon should be administered via intramuscular injection just ventral to the dorsal fin for one (1) to three (3) injections. Any single injection should be administered, depending on the fish species, at a dose of 50 to 510 I.U./lb for males and 67 to 1816 I.U./lb for females.

Presentation

Chorulon (for fish) is supplied in cartons containing five vials of freeze-dried powder (10,000 I.U. per vial) and five 10 mL vials of sterile diluent.

Storage

Store at or below room temperature, 25°C. Keep out of reach of children. Once reconstituted, Chorulon should be used immediately. Unused solution should be disposed of properly and not stored for future use.

Fair Balance

Chorionic gonadotropin is a protein. In the unlikely event of an anaphylactic reaction, epinephrine should be administered. The administration of an antihistamine may also be indicated. No withdrawal period is required for cows or brood finfish treated according to label directions. The total dose administered (all injections combined) should not exceed 25,000 I.U. (25 mL) per fish in fish intended for human consumption.

Further Information

Chorionic gonadotropin has luteinizing hormone-like activity with little or no follicle stimulating or oestrogenic activity.