Transitioning to Vetsulin ®
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Transitioning to Vetsulin® for Dogs
When transitioning a dog from another insulin product to Vetsulin®, many factors need to be considered, such as state of current regulation, duration of therapy and the presence of concurrent illness. These are some general recommendations for care:
- If regulation is considered adequate, it is suggested to start Vetsulin (porcine insulin zinc suspension) at 50%–75% of the dosage used with the previous insulin.
- If ideal regulation has not been achieved, it is important to confirm proper owner insulin administration as well as insulin handling. If no issues are discovered, the presence of an insulin resistance source (i.e. urinary tract infection) or Somogyi overswing should be investigated prior to transitioning as well.
- For an inadequately regulated dog, weigh the dog and start at labelled starting dose.
Rules for Conversion
In all cases, allow the animal to adapt to the new dosage for 5 to 7 days before adjusting the dose. It is recommended to assess the pet’s response to Vetsulin by evaluating clinical signs and performing blood glucose monitoring.
If necessary, increases in the dose should be performed in increments of 10%. If hypoglycemia is documented, the dose should be decreased. Following adjustment, wait to reevaluate until the new dose has been given for at least 5 to 7 days, unless evidence of hypoglycemia appears.
Twice-daily injections at 12-hour intervals may be indicated if the dog’s clinical signs persist and the blood glucose curve indicates a duration of activity of less than 14 to 18 hours.
From Once to Twice-daily Therapy
When switching dosage from once-daily to twice-daily, the Vetsulin dose needs to be decreased by 25%. For example, if a dog receives 20 IU of Vetsulin once daily, the new dose would be 15 IU twice daily.
Monitoring After Transition
After the dog is transitioned to Vetsulin, it is important to monitor the dog closely for signs of dysregulation as well as hypoglycemia.
It is not uncommon to experience a change in regulation associated with the transition between insulin products, due to differences in potency. In addition, the new product, syringe, concentration of the product or schedule of treatment may confuse the owner. Therefore, good communication at the time of transition and follow up visits are recommended.
To learn more, read the Transitioning Canine Patients with Diabetes Mellitus to Vetsulin® conversion chart.
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Learn More About Dosing & Administration
Important Safety Information:
Vetsulin® should not be used in dogs known to have a systemic allergy to pork or pork products. Vetsulin is contraindicated during periods of hypoglycemia. Keep out of reach of children. As with all insulin products, careful patient monitoring for hypoglycemia and hyperglycemia is essential to attain and maintain adequate glycemic control and prevent associated complications. Overdosage can result in profound hypoglycemia and death. The safety and effectiveness of Vetsulin in puppies, breeding, pregnant, and lactating dogs has not been evaluated. See package insert for full information regarding contraindications, warnings, and precautions.
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