Shown to be effective for vaccination of healthy dogs 8 weeks of age or older against canine distemper virus, canine adenovirus type 1 (hepatitis), canine parainfluenza virus, canine parvovirus, L. grippotyphosa, L. pomona, L. icterohaemorrhagiae, and L. canicola. Also effective against mortality and leptospiruria (shedding of Leptospira in the urine) caused by L. canicola,
L. icterohaemorrhagiae, L. pomona and L. grippotyphosa.