Shown to be effective for the vaccination of healthy dogs 8 weeks of age or older against canine distemper virus, canine adenovirus type 1 (hepatitis), canine parainfluenza virus, canine parvovirus, Leptospira canicola, L. icterohaemorrhagiae, L. pomona and L. grippotyphosa.

Also shown to be effective against mortality and leptospiruria (shedding of Leptospira in the urine) caused by L. canicola, L. icterohaemorrhagiae, L. pomona and L. grippotyphosa.