Shown to be effective for vaccination of healthy dogs 8 weeks of age or older against Leptospira canicola, L. icterohaemorrhagiae, 
L. pomona and L. grippotyphosa.

Also been shown to be effective against mortality and leptospiruria (shedding of Leptospira in the urine) caused by L. canicola, 
L. icterohaemorrhagiae, L. pomona and L. grippotyphosa.