BOVILIS® NASALGEN® 3-PMH

Bovine Rhinotracheitis-Parainfluenza 3-Respiratory Syncytial Virus-Mannheimia Haemolytica-Pasteurella Multocida Vaccine

Product Description

The color of unmatched intranasal protection.
BOVILIS^® NASALGEN^® 3-PMH is the first and only intranasal BRD vaccine offering protection against IBR, BRSV, PI₃, Pasteurella multocida and Mannheimia haemolytica. It’s safe to use in calves 1 week of age and older for a strong, healthy foundation. And a unique BluShadow^® diluent means there’s no second-guessing which animals have been vaccinated.

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Indications

This product has been shown to be effective for the vaccination of healthy cattle, 1 week of age or older against infectious Bovine Rhinotracheitis (IBR) virus, Bovine Respiratory Syncytial Virus (BRSV), Parainfluenza 3 virus (PI3), Mannheimia haemolytica and Pasteurella multocida. Duration of immunity against IBR is at least 195 days, against BRSV is at least 78 days, against PI3 is at least 95 days, against Mannheimia haemolytica is at least 122 days, and against Pasteurella multocida is at least 125 days.

Diseases

Infectious bovine rhinotracheitis (IBR)
Bovine respiratory syncytial virus (BRSV)
Parainfluenze 3 (PI₃)
M. haemolytica
P. multocida

Key Benefits

Designed with IBR strains that are not temperature-sensitive.¹ Ensures the vaccine will replicate and protect in any situation.
Unique BluShadow® diluent for confident administration.
Eliminates the need and stress of two separate vaccines.
Safe in pregnant cows and in calves nursing pregnant cows.

Powerful, long-lasting duration of immunity²

At least 195 days against IBR
At least 95 days against PI₃
At least 78 days against BRSV
At least 125 days against P. multocida
At least 122 days against M. haemolytica

Usage

Convenient, single 2 mL does in one nostril
Mimics natural exposure to the most common causes of pneumonia for an effective immune response

A Game-changing Vaccine

Innovation is critical in vaccine development. For decades it was believed that vaccinating young animals was not effective because of maternal antibody interference. The industry needed to find a way to protect young calves from BRD.

Learn from members of the team who brought to market BOVILIS NASALGEN 3-PMH – the first and only intranasal BRD vaccine offering protection against viral and bacterial pathogens.

Don’t leave a gap in your protection

In addition to BRD, bovine viral diarrhea (BVD) is widespread, serious and costly. And most herds are at risk.
By combining all the benefits of BOVILIS NASALGEN 3-PMH with the added BVD coverage of BOVILIS® VISTA® BVD CFP, you can get calves off to a strong start.

No other combination offers more when it comes to coverage and duration.

provides the most complete coverage – proven effective against both BVD Type 1b and Pasteurella multocida – that the Zoetis^® option lacks.

BVD Type 1b accounts for more than two-thirds of BVD-positive cattle – duration and cross protection are key as maternal antibody protection wears off.³
Pasteurella multocida is the second most isolated bacteria recovered from lung samples at Midwestern diagnostics labs – and young calves are especially susceptible.⁴

The first and only intranasal vaccine with viral and bacterial pneumonia protection.

That means protection against IBR, BRSV, PI₃, Pasteurella multocida and Mannheimia haemolytica. BOVILIS NASALGEN 3-PMH is also safe to use in calves 1 week of age or older for a strong, healthy foundation. And a unique BluShadow^® diluent means there’s no second-guessing which animals have been vaccinated.

Dosage

Shake well and administer a 2 mL dose by the intranasal route. For advice on revaccination frequency, contact your veterinarian.

Supplied

20 mL x 10 doses (2 mL per dose)
25 mL x 1 dose/2 mL x 25 doses (2mL per dose)
100 mL x 50 doses (2 mL per dose)

Caution

Store at 2 to 8°C (35 to 46°F). Fetal health risks associated with the vaccination of pregnant animals with this vaccine cannot be unequivocally determined during clinical trials conducted for licensure. Appropriate strategies to address the risks associated with vaccine use in pregnant animals should be discussed with a veterinarian. Use entire contents when first opened. Do not use chemical disinfectants to sterilize syringes or needles. Do not mix with other products, except as specified on the label. Inactivate unused contents before disposal. Do not vaccinate within 21 days of slaughter. Anaphylactoid reactions may occur following use. Antidote: Epinephrine. Contains Penicillin and Streptomycin as a preservative. In case of human exposure, contact a physician.
FOR ANIMAL USE ONLY.

Research

Efficacy of the Pasteurella multocida Fraction of BOVILIS® Nasalgen® 3-PMH in Calves 1 to 4 Days Old

Duration of Immunity of the Pasteurella multocida Fraction of BOVILIS® Nasalgen® 3-PMH Administered to Calves at 2 to 3 Days of Age

Efficacy of the Mannheimia haemolytica Fraction of BOVILIS® Nasalgen® 3-PMH in Calves 2 to 4 Days Old

Duration of Immunity of the Mannheimia haemolytica Fraction of BOVILIS® Nasalgen® 3-PMH Administered to Calves 4 to 6 Days of Age

Efficacy of the Bovine Respiratory Syncytial Virus Fraction of BOVILIS® Nasalgen® 3-PMH in Calves 4 to 7 Days Old

Duration of Immunity of the Bovine Respiratory Syncytial Virus Fraction of BOVILIS® Nasalgen® 3-PMH Administered to Calves 5 to 7 Days of Age

Efficacy of the Infectious Bovine Rhinotracheitis Fraction of BOVILIS® Nasalgen® 3-PMH in Calves 4 to 7 Days Old

Duration of Immunity of the Infectious Bovine Rhinotracheitis Virus Fraction of BOVILIS® Nasalgen® 3-PMH Administered to Calves 3 to 5 Days of Age

Efficacy of the Bovine Parainfluenza 3 Virus Fraction of BOVILIS® Nasalgen® 3-PMH in Calves 6 or 7 Days Old

Duration of Immunity of the Parainfluenza 3 Fraction of BOVILIS® Nasalgen® 3-PMH Administered to Calves 3 to 5 Days of Age

Contact

U.S. only: Merck Animal Health contact us or call 1-800-211-3573.
For more information regarding efficacy and safety data, go to productdata.aphis.usda.gov
For additional information, please see the product label.

Sources

Grissett GP, et al. Effect of Ambient Temperature on Viral Replication and Serum Antibody Titers Following Administration of a Commercial Intranasal Modified-Live Infectious Bovine Rhinotracheitis-Parainfluenza-3 Virus Vaccine to Beef Cattle Housed in High- and Moderate-Ambient Temperature Environments. Am J Vet Res. 2014;75(12):1076-1082.
See Product Label.
Meyer B, Hill K, Burdett B, Engelken TJ, Roth J, Renter D. et al. Haptoglobin Study of Vista in young beef calves. Bov Pract. 2014.
Andersen PH. Bovine Endotoxin. Some aspects of relevance to production diseases. A Review. Acta Vet Scand Suppl. 2003;98:141-155.

For more cattle-friendly options, see the rest of the Merck Animal Health vaccine lineup.

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