BRAVECTO® Quantum

1 quick injection. 1 full year* of flea and tick protection for dogs.¹

Product Description

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Take control with year-long* protection that’s only administered by veterinary professionals like you.

Only BRAVECTO QUANTUM utilizes a unique, patented composition of fluralaner, one of the world’s most trusted flea and tick medications.

Administered subcutaneously via aqueous suspension

The extended-release composition delivers effective levels of fluralaner for 12 months*

We stand behind our products with our BRAVECTO Brand Promise

Indications

BRAVECTO QUANTUM kills adult fleas and is indicated for the treatment and prevention of flea infestations (Ctenocephalides felis) and for the treatment and control of tick infestations [Ixodes scapularis (black-legged tick), Dermacentor variabilis (American dog tick), Rhipicephalus sanguineus (brown dog tick), Haemaphysalis longicornis (Asian longhorned tick), and Amblyomma maculatum (Gulf Coast tick)] for 12 months in dogs and puppies 6 months of age and older.

BRAVECTO QUANTUM is also indicated for the treatment and control of Amblyomma americanum (lone star tick) infestations for 8 months in dogs and puppies 6 months of age and older.

Kills fleas and ticks in dogs 6 months of age and older with a single injection.*

Cat Flea –
ctenocephalides felis

Black-legged tick –
ixodes scapularis

Brown Dog Tick – rhipicephalus sanguineus

American Dog Tick – dermacentor variabilis

Asian longhorned tick – Haemaphysalis longicornis

Gulf coast tick – Amblyomma maculatum

Lone Star Tick – amblyomma americanum

The first single-dose year-long flea protection

BRAVECTO QUANTUM prevents flea infestations by killing fleas before they can lay eggs.

100% effective against adult fleas by 48 hours after treatment²

Onset of efficacy study against ctenocephalides felis (cat flea)^{2 ✝}

✝ Onset of efficacy is defined as the time following treatment administration to achieve a ≥90% reduction in live flea counts.
‡ Flea counts are in arithmetic means. Percent effectiveness is based on arithmetic means.

≥99.7% effective against adult fleas 24 hours post-infestation from 1 week through 12 months after treatment²

Flea efficacy-adulticide^{2 §}

§ Flea counts are arithmetic means. Percent effectiveness is based on arithmetic means.

100% effective in eliminating egg production for 365 days²

Flea efficacy-egg production^{2 ||}

|| Flea egg counts are arithmetic means.

The most extended efficacy against serious tick-borne threats

BRAVECTO QUANTUM provides the longest-lasting tick protection available in a single dose.*

Remained ≥94% effective against Rhipicephalus sanguineus from Day 7 through Day 365²

Duration of efficacy studies against R sanguineus (Brown Dog Tick)^{2 ¶}

¶ Tick counts are arithmetic means. Percent effectiveness is based on arithmetic means.

Onset of efficacy immediately following treatment²

Asian longhorned tick (Haemaphysalis longicornis)

Dermacentor variabilis (American dog tick)

Gulf coast tick
(Amblyomma maculatum)

Ixodes scapularis
(black-legged tick)

Rhipicephalus sanguineus
(brown dog tick)

Amblyomma americanum
(lone star tick)

Demonstrated safety of BRAVECTO QUANTUM

BRAVECTO QUANTUM has been safely administered in numerous clinical studies to dogs of various ages, weights, and breeds, including mixed-breeds.²

The most commonly reported adverse reactions in a US field study included lethargy, decreased appetite, vomiting, diarrhea, elevated liver enzymes and pruritus.

Percentage of Dogs with Adverse Reactions in the Field Study

Adverse Reaction (AR)	BRAVECTO QUANTUM (n = 225 dogs)	Active Control (n = 96 dogs)
Lethargy	4.9%	3.1%
Decreased appetite	4.4%	4.2%
Vomiting	4.0%	0%
Diarrhea	2.7%	3.1%
Liver enzymes (serum ALT or ALP) greater than twice the upper reference range	2.7%	2.1%
Pruritus	1.8%	2.1%
Injection site lumps or swelling	1.3%	0%
Seizures	0.9%	0%

Accurate dosing for dogs of any size

Multi-dose vial allows you to draw the exact dose you need for dogs of any size (15 mg fluralaner/kg body weight; 0.1 mL/kg body weight).

How to mix BRAVECTO QUANTUM

Watch the video to see how to constitute BRAVECTO QUANTUM prior to administration.

Frequently Asked Questions about BRAVECTO QUANTUM

Safety

WHY IS THE PRODUCT ONLY INDICATED FOR DOGS FROM 6 MONTHS OF AGE?

Due to the possibility of fast-growing puppies outgrowing the dose, the product was developed for dogs and puppies 6 months of age and older.¹

HOW DO I KNOW THAT BRAVECTO QUANTUM IS SAFE FOR MY PATIENTS?

A margin of safety study was performed and demonstrated safety at doses of 1X (15mg/kg), 3X (45mg/kg), and 5X (75mg/kg) administered every 4 months for a total of 6 doses.² The most commonly reported adverse reactions in a US field study included lethargy, decreased appetite, vomiting, diarrhea, elevated liver enzymes and pruritus.

Concurrent administration

CAN THE PRODUCT BE ADMINISTERED AT THE SAME TIME AS VACCINES?

In a well-controlled field study, BRAVECTO QUANTUM was used concurrently with other medications, such as vaccines, anthelmintics, antibiotics (including topical), steroids, analgesics, and anesthetics. No adverse reactions were observed from the concurrent use of BRAVECTO QUANTUM with other medications.¹

Dosing

WHY IS AN 18 G NEEDLE REQUIRED FOR ADMINISTRATION?

The formulation is a suspension containing fluralaner powder, and an 18 G needle is required to ensure the suspension is accurately transferred from the vial into the syringe and from the syringe into the patient. Shake the fluralaner powder vial thoroughly.

HOW MUCH VOLUME IS GIVEN PER DOG?

Dogs should be dosed at 0.1 mL per kg (.045 mL per lb) of body weight. Dogs weighing 10 kg (22 lbs) should be injected with 1.0 mL; dogs weighing 15 kg (33 lbs) should be injected with 1.5 mL, etc.

WHEN CAN DOGS START BRAVECTO QUANTUM?

Because the efficacy is sustained for an entire year following administration, dogs can be treated whenever they are unprotected against fleas and ticks. Dogs will not require another dose of flea and tick treatment for 12 months for the indicated parasites.¹

BRAVECTO QUANTUM kills adult fleas, prevents flea infestations and treats and controls ticks (black-legged tick, American dog tick, brown dog tick, Asian longhorned tick and Gulf Coast tick) for 12 months. BRAVECTO QUANTUM also kills lone star ticks for 8 months. BRAVECTO QUANTUM should be administered every 8 months in the case of potential exposure to Amblyomma americanum ticks.

HOW SOON MUST THE PRODUCT BE USED AFTER IT IS MIXED, AND HOW MUST IT BE STORED?

Before every use, shake the constituted vial vigorously for 30 seconds to achieve a uniform suspension prior to drawing up a dose. The product should be administered within 2 minutes of being drawn into the syringe. Discard vial 3 months after first puncture.

What is the frequency of treatment?

BRAVECTO QUANTUM should be administered as a single subcutaneous dose every 12 months. BRAVECTO QUANTUM should be administered every 8 months in the case of potential exposure to Amblyomma americanum (lone start tick).

General Product Information

WHY IS ONE VIAL DARK IN COLOR AND THE OTHER IS COLORLESS?

The sterilization process used for the powder causes the glass to darken in color, which is not the case for the process used to sterilize the liquid vehicle.

WHERE IS THE PRODUCT MANUFACTURED?

The product is manufactured in Germany.

HOW DO I ORDER THE PRODUCT?

BRAVECTO QUANTUM is offered directly through the Merck Animal Health online ordering platform, eShop. Please reach out to your Merck Animal Health Outside or Inside Sales Representative to learn how to access the platform.

Resources

Clinic Tools

Download Bravecto clinic tools and in-clinic screens for your veterinary practice.

For technical assistance or to report a suspected adverse drug reaction, contact Merck Animal Health at 1-800-224-5318.

This site is intended for veterinary professionals. Visit our website for pet owners.

*BRAVECTO QUANTUM kills adult fleas, prevents flea infestations and treats and controls ticks (black-legged tick, American dog tick, brown dog tick, Asian longhorned tick and Gulf Coast tick) for 12 months. BRAVECTO QUANTUM also kills lone star ticks for 8 months. BRAVECTO QUANTUM should be administered every 8 months in the case of potential exposure to lone star ticks.

Important Safety Information

Fluralaner belongs to the isoxazoline class, which has been associated with neurologic adverse reactions (e.g., tremors, ataxia, and seizures). Seizures have been reported in dogs receiving isoxazoline class drugs, even without a history of seizures. Use with caution in dogs with a history of seizures or neurologic disorders. BRAVECTO QUANTUM is not effective against Amblyomma americanum (lone star tick) beyond 8 months after dosing. Hypersensitivity reactions, including anaphylaxis, have been reported and should be treated immediately with the same measures used to treat hypersensitivity reactions to vaccines and other injectable products. The safety of BRAVECTO QUANTUM has not been evaluated in breeding, pregnant and lactating dogs. Reproductive adverse events have been reported following use of BRAVECTO (fluralaner) Chews in breeding females. For use in dogs and puppies 6 months of age and older. The most commonly reported adverse reactions in a US field study include lethargy, decreased appetite, vomiting, diarrhea, elevated liver enzymes and pruritus. For complete safety information, refer to the product label.

References