PrimeVACâ„¢ preconditioning programs for healthier, higher-value calves
Precondition Your Success
With PrimeVAC
PrimeVAC preconditioning programs by Merck Animal Health offer a comprehensive mix of proven products and protocols that boost calf health, performance and marketability. Veterinarian-approved PrimeVAC certifications help build credibility and provide value-added premiums for your calves on sale day. With different options available, select the PrimeVAC program that works best for your operation’s goals.
PrimeVAC focuses on three essential areas of protection:
- Respiratory viruses and bacteria
- Clostridial disease
- Internal parasites
PrimeVAC also includes elective implant options.
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Talk to your veterinarian or Merck Animal Health representative to find the PrimeVAC program that’s right for your operation.
PrimeVAC certified calves on the VAC45 protocol added $48.39 more per head, compared to those of VAC24.1
Pick Your Program
Learn about the different PrimeVAC programs available. Below are program recommendations, but visit with your vet on the different product options available.
PrimeVAC24 | Calves vaccinated once prior to weaning.

First vaccination: Prior to or at weaning
RESPIRATORY
Select a MLV vaccine (IBR, BVDV 1, 1b & 2, PI3, BRSV) + H & PM, such as
BOVILIS® VISTA® ONCE SQ
CLOSTRIDIAL/BLACKLEG
Select a proven clostridial vaccine like
BOVILIS® VISION® 7 WITH SPUR®* or
BOVILIS® VISION® 7 SOMNUS With SPUR®*
PINK EYE VACCINATON
(Optional but recommended)
Select one:
BOVILIS® 20/20 VISION® 7 WITH SPUR®*
BOVILIS® PILIGUARD® PINKEYE
INTERNAL PARASITE CONTROL
(Optional but recommended)
Select one:
SAFE-GUARD® (fenbendazole)
PANACUR® (fenbendazole)
EXTERNAL PARASITE CONTROL
(Optional but recommended)
Select one:
ULTRA BOSS® Pour-On
ULTRA SABER® Pour-On
IMPLANT
(Optional but recommended)
Select an optional implant like
RALGRO® (zeranol implants)
PrimeVAC34 | Calves are vaccinated twice prior to weaning.

First vaccination: Prior to or at weaning
RESPIRATORY
Select a MLV viral vaccine (IBR, BVDV 1, 1b & 2, PI3, BRSV) + MH & PM, such as
BOVILIS® VISTA® ONCE SQ
CLOSTRIDIAL/BLACKLEG
Select a proven clostridial vaccine like
BOVILIS® VISION® 7 WITH SPUR®* or
BOVILIS® VISION® 7 SOMNUS With SPUR®*
PINK EYE VACCINATON
(Optional but recommended)
Select one:
BOVILIS® 20/20 VISION® 7 WITH SPUR®*
BOVILIS® PILIGUARD® PINKEYE
INTERNAL PARASITE CONTROL
(Optional but recommended)
Select one:
SAFE-GUARD® (fenbendazole)
PANACUR® (fenbendazole)
EXTERNAL PARASITE CONTROL
(Optional but recommended)
Select one:
ULTRA BOSS® Pour-On
ULTRA SABER® Pour-On
Second vaccination: 3-6 weeks after first dose
RESPIRATORY
Give second dose of selected option.
CLOSTRIDIAL/BLACKLEG
Give second dose of selected option.
PINK EYE VACCINATON
Give second dose of selected option.
PrimeVAC45 | For home-raised, single-source ranch calves weaned a minimum of 45 days prior to delivery.

First vaccination: Prior to or at weaning
RESPIRATORY
Select a MLV viral vaccine (IBR, BVDV 1, 1b & 2, PI3, BRSV) + MH & PM, such as
BOVILIS® VISTA® ONCE SQ
CLOSTRIDIAL/BLACKLEG
Select a proven clostridial vaccine like
BOVILIS® VISION® 7 WITH SPUR®* or
BOVILIS® VISION® 7 SOMNUS With SPUR®*
PINK EYE VACCINATON
(Optional but recommended)
Select one:
BOVILIS® 20/20 VISION® 7 WITH SPUR®*
BOVILIS® PILIGUARD® PINKEYE
INTERNAL PARASITE CONTROL
(Optional but recommended)
Select one:
SAFE-GUARD® (fenbendazole)
PANACUR® (fenbendazole)
EXTERNAL PARASITE CONTROL
(Optional but recommended)
Select one:
ULTRA BOSS® Pour-On
ULTRA SABER® Pour-On
IMPLANT
(Optional but recommended)
Select an optional implant like
Recommended at branding:
RALGRO® (zeranol implants)
Recommended at backgrounding:
Select one:
RALGRO® (zeranol implants)
REVALOR®-G (trenbolone acetate and estradiol implants)
Second vaccination: 3-6 weeks after first dose
RESPIRATORY
Give second dose of selected option.
CLOSTRIDIAL/BLACKLEG
Give second dose of selected option.
PINK EYE VACCINATON
Give second dose of selected option.
PrimeVAC Heifer45 | For home-raised replacement heifers.
Replacement heifers are vaccinated three times.

First vaccination: Prior to or at weaning
RESPIRATORY
Select a MLV viral vaccine (IBR, BVDV 1, 1b & 2, PI3, BRSV) + MH & PM, such as
BOVILIS® VISTA® ONCE SQ
CLOSTRIDIAL/BLACKLEG
Select a proven clostridial vaccine like
BOVILIS® VISION® 7 WITH SPUR®* or
BOVILIS® VISION® 7 SOMNUS With SPUR®*
PINK EYE VACCINATON
(Optional but recommended)
Select one:
BOVILIS® 20/20 VISION® 7 WITH SPUR®*
BOVILIS® PILIGUARD® PINKEYE
INTERNAL PARASITE CONTROL
(Optional but recommended)
Select one:
SAFE-GUARD® (fenbendazole)
PANACUR® (fenbendazole)
EXTERNAL PARASITE CONTROL
(Optional but recommended)
Select one:
ULTRA BOSS® Pour-On
ULTRA SABER® Pour-On
IMPLANT
(Optional but recommended)
Select an optional implant like
Recommended at branding:
RALGRO® (zeranol implants)
Recommended at backgrounding:
Select one:
RALGRO® (zeranol implants)
REVALOR®-G (trenbolone acetate and estradiol implants)
Second vaccination: 3-6 weeks after first dose
RESPIRATORY
Give second dose of selected option.
CLOSTRIDIAL/BLACKLEG
Give second dose of selected option.
PINK EYE VACCINATON
Give second dose of selected option.
Third vaccination: 2-8 weeks prior to breeding
REPRODUCTIVE PROTECTION
Provide comprehensive fetal protection with a single-dose of
BOVILIS® VISTA® 5 VLS SQ
CLOSTRIDIAL/BLACKLEG
Give third dose of selected option.
INTERNAL PARASITE CONTROL
Give second dose of selected option.
The Importance of Stockmanship
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PrimeVAC preconditioning programs outline the products and protocols you should be using to help ensure the health of your calves. Along with these products, stockmanship practices can help ensure success year after year. This includes:
- Acclimating calves to the feed bunk and water tank
- Castrating bulls and dehorning calves at the youngest age possible
- Uniquely identifying calves with high-quality, easily readable ALLFLEX® ear tags
Protection That Pays
PrimeVAC represents Merck Animal Health’s commitment to finding a better way forward through game-changing advancements, protocols and vaccine innovations. Learn the stories behind some of these vaccines.
PrimeVAC – Deana Hardee, DVM:
Beef Technical Services Veterinarian
PrimeVAC – Tyler Richter:
Watson Ranch
Bring PrimeVAC success to your operation. Talk to your veterinarian or Merck Health Representative to learn more about implementing a PrimeVAC preconditioning program.
References
- Superior Livestock Auction Data 2024.
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