Lepto₄ Vaccine

Protects against disease, mortality and urinary shedding. Featuring an even higher level of quality due to VacciPure^™ filtration.

NOBIVAC LEPTO₄ PROVIDES PROVEN PROTECTION AGAINST LEPTOSPIROSIS

The four-way leptospirosis vaccine is shown to be effective against disease, mortality and leptospiruria.

PRODUCT LABEL

Aid in the prevention of disease and mortality caused by 4 virulent Leptospira serovars²¹
Protects against liver dysfunction and thrombocytopenia¹
The only vaccine indicated to protect against mortality and leptospiruria
Prevents leptospiremia²²
Proven safe and well tolerated in multiple studies¹
Available in both a stand-alone and combination formulation (DAPPv)

INDICATIONS:

Shown to be effective against disease and mortality caused by L. canicola, L. icterohaemorrhagiae, L. pomona, or L. grippotyphosa.

Prevents leptospiruria associated with L. grippotyphosa, L. canicola, or L. icterohaemorrhagiae.

Aids in the prevention of leptospiruria associated with L. pomona.

Recommended for use in healthy dogs 8 weeks of age or older.

Unmatched Protection of Nobivac^® Lepto₄:Two Critical Indications

1. SHEDDING: DEFENSE AGAINST URINARY SHEDDING CAUSED BY 4 KEY LEPTOSPIRA SEROVARS

PREVENT URINARY SHEDDING OF LEPTOSPIRES²²

A key objective of vaccination is to prevent urinary shedding of leptospires, which has potential zoonotic risk:^22,23

0% of dogs vaccinated with Nobivac^® Canine 1-DAPPv+L₄ developed leptospiruria
All of the control dogs challenged with L. canicola and L. grippotyphosa, 80% of control dogs challenged with L. icterohaemorrhagiae, and 50% of control dogs challenged with L. pomona developed leptospiruria

Nobivac^® Lepto₄ is shown to be effective against leptospiruria associated with

L. grippotyphosa
L. canicola
L. icterohaemorrhagiae
L. pomona

UNMATCHED PROTECTION

NOBIVAC LEPTO₄ IS THE CLEAR CHOICE WHEN COMPARED WITH OTHER 4-WAY LEPTOSPIROSIS VACCINES^24-27

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VacciPure^™Filtration Technology

THE ADVANCED VACCIPURE™ FILTRATION TECHNOLOGY

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FILTRATION PROCESS LEADS TO IMPROVED VACCINES¹

To promote an even higher level of vaccine quality, Merck Animal Health introduced the unique VacciPure filtration process for manufacturing Nobivac^® Lepto₄ and Nobivac^® Canine 1-DAPPV+L_4.