Newsroom

August 8, 2024

Efficacy of fluralaner flavored chews (Bravecto®) administered to dogs against the adult cat flea, Ctenocephalides felis felis and egg production

Abstract Background: Fluralaner is a potent insecticide and acaricide with rapid and persistent efficacy. This study measured the efficacy of fluralaner flavored chews (Bravecto®, Merck Animal Health) administered to dogs against adult Ctenocephalides felis felis and egg production. Methods: Twelve purpose-bred dogs were randomly allocated to two groups of six dogs each. Dogs in treatment […]

August 8, 2024

Open field study on the efficacy of oral fluralaner for long-term control of flea allergy dermatitis in client-owned dogs in Ile-de-France region

Abstract Background: Fluralaner is the first orally administered isoxazoline to provide 12 weeks of activity against fleas and ticks after a single administration. As a result of its potent anti-flea activity, oral fluralaner may be proposed as a component of a strategy for the control of flea allergy dermatitis (FAD) in dogs. The open field […]

August 7, 2024

Analysis of gaps in feline ectoparasiticide purchases from veterinary clinics in the United States

Abstract Background: The study objective was to examine cat owner ectoparasiticide purchases in the United States and estimate the impact of purchase gaps on timely ectoparasite protection administration. These purchase gaps lead to periods of time when cats are unprotected from ectoparasites. Methods: Ectoparasiticide purchase transactions for individual cats from 671 U.S. veterinary clinics from […]

September 24, 2020

The effect of food on the pharmacokinetics on oral fluralaner in dogs

Abstract Background: Fluralaner is a novel systemic ectoparasiticide for dogs providing long-acting flea- and tick-control after a single oral dose. The pharmacokinetics of orally administered drugs may be influenced by feeding. This study investigated the influence of concurrent feeding on fluralaner pharmacokinetics. Methods: Twelve fasted or fed beagles received a single oral administration of 25 […]

September 24, 2020

Pharmacokinetics of fluralaner in dogs following a single oral or intravenous administration

Abstract Background: Fluralaner is a novel systemic insecticide and acaricide. The purpose of these studies was to investigate the pharmacokinetic properties of fluralaner in Beagle dogs following single oral or intravenous (i.v.) administration. Methods: Following the oral administration of 12.5, 25 or 50 mg fluralaner/kg body weight (BW), formulated as chewable tablets or i.v. administration […]

September 24, 2020

Plasma pharmacokinetic profile of fluralaner (BRAVECTO™) and ivermectin following concurrent administration to dogs

Abstract Background: Fluralaner is a novel systemic ectoparasiticide for dogs providing immediate and persistent flea, tick and mite control after a single oral dose. Ivermectin has been used in dogs for heartworm prevention and at off label doses for mite and worm infestations. Ivermectin pharmacokinetics can be influenced by substances affecting the p-glycoprotein transporter, potentially […]