Canine Adenovirus Type 2

Disease Overview

Canine adenovirus type 2 (CAV-2) is related to the hepatitis virus, canine adenovirus type 1 (CAV-1). CAV-2 is used in vaccines to provide protection against canine infectious hepatitis. CAV-2 is also one of the causes of infectious tracheobronchitis, also known as canine cough. 30

Merck Animal Health Solutions

For Canine Adenovirus Type 2


Adenoviruses are spread directly from dog to dog through infected respiratory secretions or by contact with contaminated feces or urine.

Clinical Signs30

Respiratory disease (CAV-2)

  • Dry, hacking cough (dogs)
  • Retching
  • Sneezing
  • Watery nasal discharge
  • Pneumonia, inappetence, fever, and lethargy in severe cases

Hepatitis (CAV-1)

  • Fever
  • Abdominal pain
  • Vomiting
  • Diarrhea

Risk Factors

  • Dogs that come from shelters, rescue centers, breeding kennels, or pet stores
  • Boarding at a kennel or doggie daycare
  • Visiting groomers, dog parks, or engaging with other dogs on a daily basis
  • Dogs that live in multi-pet homes


1. Greene C. Infectious canine hepatitis and canine acidophil cell hepatitis. In: Greene CE, ed. Infectious Diseases of the Dog and Cat. 3rd ed. St. Louis, MO: Saunders/Elsevier; 2006:43.