Leptospirosis is a Preventable,
Widespread Disease

Nobivac® Lepto4 is the only leptospirosis vaccine available that is shown to be effective against disease, shedding, and mortality with reduced risk of unwanted vaccine reactions.

What to Do if Your Clinic Experiences Leptospirosis

Learn Easy Ways to Talk to Your Clients About Leptospirosis

Transmission of Leptospirosis

Infected animal urinates in water or on wet ground.

Dog plays, swims or drinks from contaminated water.

Dog contracts leptospirosis through contact with urine of infected animal and becomes a carrier.


Reported cases of zoonotic diseases are on the rise, and are expected to continue to increase47,48

  • Prevalence of canine leptospirosis has increased in recent years47,48
  • As many as 8.2% of dogs are shedding leptospires, some asymptomatically49
  • Weather changes, population growth, and habitat encroachment have all increased human and canine exposure to pathogens and their carriers47,48

Leptospirosis Risks

Leptospirosis Presents Multiple Threats to Your Patients

Dogs at Risk

  • Access to ponds, lakes, streams, standing water, or puddles
  • Exposure to urine from other infected animals or through contaminated water

Dogs at greatest risk for developing leptospirosis include those with:23

Spreading Disease

As leptospirosis progresses, it can result in Leptospiruria (urinary shedding)23

Morbidity Threats

As leptospirosis progresses, it can result in:23

  • Vascular damage
  • Thrombocytopenia
  • Severe kidney and liver damage

Unmatched Protection of Nobivac® Lepto4

The first and only 4-way canine leptospirosis vaccine specifically shown to be effective against disease, mortality and leptospiruria (urinary shedding).

2 Critical Indications

1- SHEDDING: defense against urinary shedding caused by 4 key Leptospira serovars

Nobivac® Lepto4 has shown to be effective against leptospiruria associated with

  • L. grippotyphosa
  • L. canicola
  • L. icterohaemorrhagiae
  • L. pomona
2- MORTALITY: the only leptospirosis vaccine shown to be effective against disease and mortality

Protection for Dogs Facing the Most Severe Challenges

Clinical efficacy results showed that Nobivac® Canine 1-DAPPv+L4 also prevented1

  • Leptospiremia
  • Liver dysfunction
  • Thrombocytopenia

Nobivac® Lepto4 Offers Unmatched Protection24-27

Nobivac® Lepto4 is the clear choice when compared with other 4-way leptospirosis vaccines.

Vaccipure Filtration Technology

A Strategic Advance:
VacciPure Filtration Technology1

Merck Animal Health has introduced the special VacciPure filtration process in manufacturing Nobivac Nobivac® Lepto4 and Nobivac® Canine 1-DAPPv+L4 to promote an even higher level of vaccine quality.

A porous filtration membrane selectively removes extraneous proteins, salts, and solvents

  • The outcome – fewer total proteins and a more purified final product