Pasteurella multocida Vaccine

Product Description

PM-ONEVAX-C vaccine is a live bacterial vaccine containing the mild avirulent PM-1 strain of Pasteurella multocida in a freeze-dried preparation sealed under vacuum. The seed culture used to make this vaccine has been laboratory tested for protection in chickens against challenge with the X-73 (Type 1) strain of P. multocida and in turkeys against challenge with the P1059 (Type 3) strain of P. multocida.


This product has been shown to be effective for the vaccination of healthy chickens 10 to 12 weeks of age against pasteurellosis (fowl cholera) due to Pasteurella multocida Type 1 and turkeys 15 weeks of age or older against pasteurellosis (fowl cholera) due to Pasteurella multocida Type 3.


  • A temperature sensitive mutant of the CU strain that produces stronger takes than the M-9 strain, but less than the CU strain
  • Offers protection against naturally occurring field strains of P. multocida
  • Easy wing-web administration in broiler breeders, layers and turkey breeders


  • Pasteurella multocida – Fowl cholera

When To Vaccinate

Chickens: Use by wing web stab to vaccinate chickens 10-12 weeks of age.

Turkeys: Use by wing-web stab to vaccinate turkey breeders 15-18 weeks of age.

Vaccination Programs

Many factors must be considered in determining the vaccination program for a particular farm or poultry operation. To be fully effective, the vaccine must be administered to healthy receptive birds held in proper environment under good management. In addition, the response may be modified by the age of the birds and their immune status. Seldom does 1 vaccination under field conditions produce complete protection for all individuals in a given flock. The amount of protection required will vary with the type of operation and the degree of exposure that a flock is likely to encounter.


Chickens: Initial vaccination in chickens over 12 weeks of age may be undesirable because larger granulomas may develop at the site of inoculation and this may result in downgrading of carcasses at slaughter.

Turkeys: Use of this vaccine in turkeys which have not been orally prevaccinated may cause severe postvaccination reactions, including lameness and death. The interval between the last oral vaccination and the first wing-web vaccination should not exceed 6 weeks.

How To Vaccinate

1. Vaccination is accomplished by dipping the needle applicator into the mixed vaccine and piercing the webbed portion of the underside of the wing. Avoid piercing through feathers which may wipe off the vaccine and avoid hitting the wing muscle or bone to minimize reaction. The applicator is designed to pick up the proper amount of vaccine on the needles, which is deposited in the tissues when the wing is pierced.
2. Redip the applicator in the vaccine before each application. Excess vaccine adhering to the applicator should be removed by touching the applicator to the inside of the vial.
3. At 5 to 10 days following vaccination, a swelling of the skin (subcutaneous granuloma) will develop on the wing-web at the point of inoculation. The absence of this local reaction may mean that improper vaccination methods were used. Examination for these “takes” at 7 days post-vaccination may be used to assure that proper vaccination has been conducted.


10 x 1,000 doses (for application with accompanying diluent)


2. All birds should be vaccinated at the same time.
3. Do not medicate birds with antibacterial drugs 3 days prior to or 5 days after vaccination.
4. Use entire contents when first opened.
5. Do not vaccinate within 21 days before slaughter.
6. Store at 2° to 8° C (35° to 46° F). Do not freeze.
7. Inactivate unused contents before disposal.
8. Do not mix with other products, except as specified on this label.
9. In case of human exposure, contact a physician.


This vaccine has undergone rigid potency, safety and purity tests, and meets Merck Animal Health, U.S. and local regulatory requirements. It is designed to stimulate effective immunity when used as directed, but the user must be advised that the response to the product depends upon many factors, including, but not limited to, conditions of storage and handling by the user, administration of the vaccine, health and responsiveness of the individual chickens and the degree of field exposure. Therefore, directions should be followed carefully. A safety data sheet (SDS) is available upon request. This and any other consumer information can be obtained by calling Merck Animal Health Customer Service at 1-800-211-3573.


Keep a record of vaccine, quantity, serial number, expiration date, and place of purchase; the date and time of vaccination; the number, age, breed, and locations of chickens; names of operators performing the vaccination and any observed reactions.

Contact our sales or technical services representatives to help design a custom vaccination program.


Fowl Cholera Vaccination Manual

Vaccination Technique and Troubleshooting


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For additional information, please see the product label.
For more information regarding efficacy and safety data, go to

*Data on file, Merck Animal Health

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