Vetsulin is the first insulin approved to manage canine and feline diabetes

Urine Testing

Read More About Monitoring & Controlling Canine Diabetes

Evaluation of Glycosuria, Ketonuria, and Monitoring

Urine only tests positive for glucose if the blood glucose concentration remains above the renal threshold for a substantial period of time. This occurs when glycemia reaches 180–220 mg/dL (10–12.2 mmol/L) in the dog.

If used in conjunction with spot glucose measurements and evaluation of clinical signs, urine sampling can be a valuable monitoring tool. However, when adjustment of insulin dose is necessary, the preferred method of monitoring is by evaluation of glycemia by performing a glucose curve.

Urine monitoring is also a quick and easy method of detecting ketones (ketonuria) and hence a potential emergency—see diabetic ketoacidosis. Unlike a blood glucose curve, urine sampling cannot confirm hypoglycemia.

Two Different Protocols Can Be Used By The Client:

1. Have pet owner test urine 3 times a day: before the first meal (test 1), before the second meal (test 2), and late in the evening (test 3).

TEST 1TEST 2TEST 3Action Recommended
TraceNone
+None
TraceTraceDuration of Vetsulin activity may be a little too short. Perform glucose curve.
++Potential Somogyi effect. Perform glucose curve.
+++Dose potentially too low. Perform glucose curve.
Dose potentially too high. Perform glucose curve.

2. Ask the pet owner to closely monitor a 24-hour period by collecting as many urine samples as possible. A persistent glycosuria will indicate the necessity of a complete re-evaluation and glucose curve.

3. Inform owner to contact you if urine glucose testing is negative at any time during the day for more than one day as this may indicate that the dog’s blood glucose is low and dosage decrease is necessary.

Resources to Help Clients Monitor Care

Help Your Practice Manage Diabetes Mellitus

View and download resources and tools that will assist your hospital, inform your team, and help with clients.

Blood Glucose Curve Generator

Create a blood glucose curve to monitor and evaluate diabetes treatments.

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Client Discharge Form

Create a customized, printable form for clients about their new diagnosis.

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Diabetes Resources

Access online tools and more to support staff and pet parents.

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Read More About Monitoring &Controlling Canine Diabetes

Important Safety Information:

Vetsulin® should not be used in dogs known to have a systemic allergy to pork or pork products. Vetsulin is contraindicated during periods of hypoglycemia. Keep out of reach of children. As with all insulin products, careful patient monitoring for hypoglycemia and hyperglycemia is essential to attain and maintain adequate glycemic control and prevent associated complications. Overdosage can result in profound hypoglycemia and death. The safety and effectiveness of Vetsulin in puppies, breeding, pregnant, and lactating dogs has not been evaluated. See package insert for full information regarding contraindications, warnings, and precautions.

References:

1. Martin GJ, Rand JS. Pharmacology of a 40 IU/ml porcine lente insulin preparation in diabetic cats: findings during the first week and after 5 or 9 weeks of therapy. J Feline Med Surg. 2001;3(1):23–30. 2. Vetsulin® (porcine insulin zinc suspension) [Freedom of Information Summary]. Millsboro, DE: Intervet Inc.; 2008. 3. Data on file, Merck Animal Health. 4. Graham PA, Nash AS, McKellar QA. Pharmacokinetics of porcine insulin zinc suspension in diabetic dogs. J Small Anim Pract. 1997;38(10):434–438. 5. Martin GJ, Rand JS. Pharmacokinetic and Pharmacodynamic Study of Caninsulin in Cats with Diabetes Mellitus. 2000: Internal Study Report. 6. Feldman EC, Nelson RW. Canine and Feline Endocrinology and Reproduction. 3rd ed. St. Louis, MO: Saunders; 2004:539–579. 7. Tennant B, ed. BSAVA Small Animal Formulary. 4th ed. Gloucestershire, UK: British Small Animal Veterinary Association; 2002. 8. Feldman EC, Nelson RW. Canine and Feline Endocrinology and Reproduction. 3rd ed. St. Louis, MO: Saunders; 2004:486–538. 9. Reusch C. Feline diabetes mellitus. In: Ettinger SJ, Feldman EC, eds. Textbook of Veterinary Internal Medicine. 7th ed. St. Louis, MO: Saunders; 2010:1796–1816. 10. Nelson RW. Canine diabetes mellitus. In: Ettinger SJ, Feldman EC, eds. Textbook of Veterinary Internal Medicine. 7th ed. St. Louis, MO: Saunders; 2010:1782–1796. 11. Burgaud S, Riant S, Piau N. Comparative laboratory evaluation of dose delivery using a veterinary insulin pen. In: Proceedings of the WSAVA/FECAVA/BSAVA congress; 12–15 April 2012; Birmingham, UK. Abstract 121. 12. Burgaud S, Guillot R, Harnois-Milon G. Clinical evaluation of a veterinary insulin pen in diabetic dogs. In: Proceedings of the WSAVA/ FECAVA/BSAVA congress; 12–15 April 2012; Birmingham, UK. Abstract 122. 13. Burgaud S, Guillot R, Harnois-Milon G. Clinical evaluation of a veterinary insulin pen in diabetic cats. In: Proceedings of the WSAVA/FECAVA/BSAVA congress; 12–15 April 2012; Birmingham, UK. Abstract 45. 14. Davison LJ, Walding B, Herrtage ME, Catchpole B. Anti-insulin antibodies in diabetic dogs before and after treatment with different insulin preparations. J Vet Intern Med. 2008;22:1317-1325. 15. Banfield State of Pet Health 2016 Report. p 12-13.