Safe-Guard® AquaSol

(fenbendazole oral suspension)

Safe-Guard® AquaSol is a suspension concentrate containing fenbendazole, an antiparasitic. Each mL of Safe-Guard® AquaSol contains 200 mg of fenbendazole.

Innovative manufacturing process enables easy, effective deworming for broilers, breeders, pullets and laying hens through oral administration via drinking water.

Chickens: Safe-Guard® AquaSol is indicated for the treatment and control of adult Ascaridia galli in broiler chickens and replacement chickens and for the treatment and control of adult A. galli and Heterakis gallinarum in breeding chickens and laying hens.

  • Approved for laying hens and replacement chickens intended to become laying hens
  • Proprietary, innovative wet-milling technique produces highly stable suspension in drinking water
  • Smaller particle size helps prevent sedimentation and clogged pipes, filters or nipple drinkers
  • Easily administered by medicators or proportioners

  • 98.8% efficacy against A. galli in 4 US field studies (100% in broilers)
  • 92.1% efficacy against H. gallinarum (long lived birds)

  • Short, 5-day treatment
  • No pre-slaughter withdrawal period when used as directed
  • Shelf life of 3 years unopened, 6 months after opening — multi-use container reduces waste

  • Proven safe when used as directed
  • No adverse effects on egg production, hatchability or progeny of breeders
  • No impact on water or feed intake compared to unmedicated controls

  • Ascaridia galli (adult stage roundworms)
  • Heterakis gallinarum (adult stage cecal worms)

Chickens: Safe-Guard® AquaSol must be administered orally to chickens via the drinking water at a daily dose of 1 mg/kg BW (0.454 mg/lb) for 5 consecutive days.

Consult your veterinarian for assistance in the diagnosis, treatment, and control of parasitism.

Chickens: Dose calculation:
The daily dose of 1 mg fenbendazole per kg BW (0.454 mg/lb) is equivalent to 0.005 mL Safe-Guard® AquaSol per kg BW (0.00227 mL/lb). The required daily volume of product is calculated from the total estimated body weight [kg] of the entire group of chickens to be treated. Please use the following formula:

Total estimated body weight [kg] of the chickens to be treated x 0.005 mL = mL Safe-Guard® AquaSol/day


Total body weight of birds to be treatedVolume of Safe-Guard® AquaSol per dayVolume of Safe-Guard® AquaSol (for 5 days)
5,000 kg (11,000 lb)25 mL5 x 25 mL = 125 mL
10,000 kg (22,000 lb)50 mL5 x 50 mL = 250 mL
80,000 kg (176,000 lb)400 mL5 x 400 mL = 2,000 mL
320,000 kg (704,000 lb)1,600 mL5 x 1,600 mL = 8,000 mL

Follow the instructions in the order described below to prepare the medicated water. The medicated water must be prepared daily prior to each administration.

Prepare a 1 to 1 dilution (pre-dilution) of Safe-Guard® AquaSol in water:
1. Calculate the volume of Safe-Guard® AquaSol to be administered daily.
2. Select a measuring device capable of accurately measuring a volume of at least twice the calculated Safe-Guard® AquaSol daily volume.

Note: If the total volume of the 1 to 1 dilution needed exceeds the volume of the largest available measuring device, divide the total volume into two or more smaller batches of 1 to 1 dilution, prepared following the steps below. Safe-Guard® AquaSol should always be measured by adding it to a measuring device that already contains an equivalent volume of water.

3. Pour a volume of water equal to the calculated volume of product needed into the measuring device.
4. Shake the product well before mixing.
5. Fill up the measuring device containing the water with the calculated volume of the product to obtain the 1 to 1 dilution.

Note: If more than the required amount of the product is accidently poured into the measuring device, discard the entire contents and repeat the process from Step 3 above.

6. Add the 1 to 1 dilution of Safe-Guard® AquaSol in water to the water supply system as described below. Be careful to avoid any accidental spill or loss of 1 to 1 dilution which may inadvertently result in less than the required dose of fenbendazole.
7. Rinse the container used to prepare the 1 to 1 dilution of Safe-Guard® AquaSol with additional water, and add the rinse water to the medicated water tank or the stock suspension tank of the dosing pump.

For use with a medication tank:
Add the entire 1 to 1 dilution of Safe-Guard® AquaSol in water to the medication tank containing the volume of drinking water usually consumed by the animals in 3 to 24 hours. Stir the medicated water in the medication tank until the medicated water is visibly homogeneous. The medicated water should appear hazy. No further stirring during administration is necessary.

For use with a dosing pump:
Add the entire 1 to 1 dilution of Safe-Guard® AquaSol in water to the water in the stock suspension tank of the dosing pump. The volume of water in the stock suspension container has to be calculated taking as a basis the present injection rate of the dosing pump and the volume of drinking water usually consumed by the animals over a period of 3 to 24 hours. Stir until the content in the stock suspension tank is visibly homogeneous. The medicated water should appear hazy.

At concentrations of up to 5 mL/L stock suspension (1 g fenbendazole/L) no stirring is required. At concentrations from 5 mL up to 75 mL of product /L stock suspension (1,000 mg to 15,000 mg fenbendazole/L) and within up to 8 hours during the treatment administration period no stirring of the stock suspension is required. If the administration period exceeds 8 hours, but being no longer than 24 hours, the stock suspension container needs to be equipped with a stirring device.

During treatment, all animals must have sole and unrestricted access to the medicated water. After complete consumption of the medicated water, the animals should have access to non-medicated drinking water ad libitum. Ensure that the total amount of medicated water offered is consumed.

1 Liter
1 Gallon

Protective gloves should be used, and care should be taken when handling the product to avoid skin and eye exposure and accidental ingestion. For customer service, adverse effects reporting, and/or a copy of the SDS, call 1-800-211-3573.
For additional information about adverse drug experience reporting for animal drugs, contact FDA at 1-888-FDA-VETS, or

Chickens: No withdrawal period is required when used according to labeling.

Parasite resistance may develop to any dewormer. All dewormers require accurate dosing for best results. Following the use of any dewormer, effectiveness of treatment should be monitored. A decrease of effectiveness over time may indicate the development of resistance to the dewormer administered. The parasite management plan should be adjusted accordingly based on regular monitoring.

Not for use in humans. Accidental exposure may result in skin and eye irritation and may cause gastrointestinal disturbances and hypersensitivity reactions in humans. No withdrawal period is required when used according to the label. Consult your veterinarian for assistance in the diagnosis, treatment and control of parasitism.

Ask your Merck Animal Health sales or technical services representative to design a custom gastrointestinal worm control program to meet your needs.

SAFE-GUARD® AquaSol Broiler Performance Improvement

Very Mild Roundworm Burden Results in Performance Loss


SAFE-GUARD® AquaSol Capillaria Screen Method

Evaluating Intestinal Capillaria Infection Using a Worm Screen


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For additional information, please see the product label.
For more information regarding efficacy and safety data, go to

1. Data on file, Merck Animal Health
2. Freedom of Information Summary, NADA 141-449

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