NUFLOR® INJECTABLE SOLUTION

NUFLOR (florfenicol) is an injectable antibiotic for the treatment of bovine respiratory disease (BRD) (with Mannheimia haemolytica, Pasteurella multocida, and Histophilus somni), bovine interdigital phlegmon (with Fusobacterium necrophorum and Bacteroides melaninogenicus) in cattle.

(florfenicol)

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Diseases/parasites

Pharmaceutical Name

Florfenicol

Features and Benefits

Injectable Solution …
controls all three major bacterial causes of bovine respiratory disease (BRD) and even treats foot rot.
Unique, fast-acting, long-lasting antibiotic for treatment of bovine respiratory disease, foot rot and control of respiratory disease in cattle at high risk of developing bovine respiratory disease.

  • Kills two major bacteria that cause BRD: Mannheimia haemolytica and Histophilus somni. Begins killing within 30 minutes and eliminates 99.9% of those bacteria within 24 hours. Continues to kill for 68 hours and remains inhibitory through 96 hours.1
  • Inhibits the third major bacterial cause of BRD: Pasteurella multocida.2
  • Effective, versatile, broad spectrum therapy in the hospital and on arrival of cattle at risk of developing BRD.
  • Lowers risk with high-risk cattle – treat on arrival.
  • Fewer repulls and retreatments.
  • Easy to use, requires no mixing or reformulation and isn’t contraindicated in automatic injection equipment.

Indications

NUFLOR Injectable Solution is indicated for treatment of bovine respiratory disease (BRD), associated with Mannheimia (Pasteurella) haemolytica, Pasteurella multocida, and Histophilus somni, and for the treatment of bovine interdigital phlegmon (foot rot, acute interdigital necrobacillosis, infectious pododermatitis) associated with Fusobacterium necrophorum and Bacteroides melaninogenicus. Also, it is indicated for the control of respiratory disease in cattle at high risk of developing BRD associated with Mannheimia (Pasteurella) haemolytica, Pasteurella multocida, and Histophilus somni.

Warnings

RESIDUE WARNINGS: Animals intended for human consumption must not be slaughtered within 28 days of the last intramuscular treatment. Animals intended for human consumption must not be slaughtered within 38 days of subcutaneous treatment. This product is not approved for use in female dairy cattle 20 months of age or older, including dry dairy cows. Use in these cattle may cause drug residues in milk and/or in calves born to these cows. A withdrawal period has not been established in pre-ruminating calves. Do not use in calves to be processed for veal.

Dosage and Administration

For treatment of bovine respiratory disease (BRD) and bovine interdigital phlegmon (foot rot):

NUFLOR Injectable Solution should be administered by intramuscular injection to cattle at a dose rate of 20mg/kg body weight (3 mL/100 lbs). A second dose should be administered 48 hours later. Alternatively, NUFLOR Injectable Solution can be administered by a single subcutaneous injection to cattle at a dose rate of 40mg/kg body weight (6 mL/100 lbs). Do not administer more than 10 mL at each site. The injection should be given only in the neck.

NOTE: Intramuscular injection may result in local tissue reaction which persists beyond 28 days. This may result in trim loss of edible tissue at slaughter. Tissue reaction at injection sites other than the neck is likely to be more severe.

For control of respiratory disease in cattle at high-risk of developing BRD:

NUFLOR Injectable Solution should be administered by a single subcutaneous injection to cattle at a dose rate of 40mg/kg body weight (6 mL/100 lbs). Do not administer more than 10 mL at each site. The injection should be given only in the neck.

Supplied

NUFLOR Injectable Solution is packaged in 100 mL (NDC 0061-1116-04), 250 mL
(NDC 0061-1116-05), and 500 mL (NDC 0061-1116-06) glass sterile multiple-dose vials.

Fair Balance

IMPORTANT SAFETY INFORMATION: NOT FOR HUMAN USE. KEEP OUT OF REACH OF CHILDREN. This product contains materials that can be irritating to skin and eyes. RESIDUE WARNINGS: Animals intended for human consumption must not be slaughtered within 28 days of the last intramuscular treatment. Animals intended for human consumption must not be slaughtered within 38 days of subcutaneous treatment. Do not use in female dairy cattle 20 months of age or older. Use of florfenicol in this class of cattle may cause milk residues. A withdrawal period has not been established in preruminating calves. Do not use in calves to be processed for veal. Not for use in animals intended for breeding purposes. The effects of florfenicol on bovine reproductive performance, pregnancy, and lactation have not been determined. Intramuscular injection may result in local tissue reaction which persists beyond 28 days. This may result in trim loss of edible tissue at slaughter. Tissue reaction at injection sites other than the neck is likely to be more severe.

Contact Information

U.S. only:
Merck Animal Health
livestocktechsrvc@merck-animal-health.con
1-800-211-3574

Website

www.nuflor.com

For additional information, please see the product label.

References:

  1. Varma, KJ, Lockwood PW, Cosgrove MS, Rogers ER, Pharmacology, Safety and Clinical Efficacy of Nuflor (florfenicol) Following Subcutaneous Administration to Cattle. Preceedings of a Symposium Held in Conjunction with the XX World Buiatrics Congress. Sydney, Australia. July 1998: 13-19.
  2. Data on file, Merck Animal Health.